Wednesday, December 18, 2024

NAC and Melatonin

 More for my reference.  Writing this stuff down helps me get it straight.

Anyway, the plot has thickened again.  A mega dose of NAC is not the answer.  Opened with a 1:52 on 30 mg of Melatonin the previous night.  Almost certainly, that dose is too high and I would do better if I cut it.  How much of a cut will be allowed before the bad reactions to NAC kick in again?  10 mg may not be enough.  I'll drop it to 25 tonight then 20 and so on.  

Despite the ill-effects of too much Melatonin, it was effective as NAC was beneficial again.  Down to 1:38 after popping just 1 of those pills (MINUS 84), which is bordering on game changer territory.  I probably would have done better than that if I just took one more NAC pill but with 3 more, I crossed the line.  My next interval was 1:49 (PLUS 66).  5 mg extra Melatonin brought it down to 1:39, basically the same as with just 1 NAC pill.  To be more concise, this means that 30 mg of Melatonin the previous night was not enough to enough to tolerate mega NAC.  I needed at least 40 and am unwilling to go that high.  

Options:

1. Cut out the NAC and stick with the 5 mg Melatonin plus the MF.  It may still be effective for the detox process but it will probably take longer.  There are 2 big negatives with that approach.  First, if I still react badly to NAC, it means that Demand #1 is not met.  Second, I will probably need Endodren to manage the detox, which is bad for my chemistry in the long run and fails Demand #2.  

2. Stick with NAC at no more than 2 pills per day in divided doses.  I will need more than 5 mg Melatonin to tolerate it but should not require anywhere near 30 mg.  A surprising advantage to this approach is that I may not need either the Thym Adren or the Endodren.

  I was encouraged yesterday when the Thym Adren really didn't do anything.  I was marginally slower but it was not significant.  On the Endodren, I was slower and it was significant.  That's what SHOULD happen when a person with overactive adrenals takes a stimulant.  It is definitely possible that toxic metals played a significant role in my adrenal imbalance.  Go through the detox with NAC and maybe I won't need any adrenal support.

I lean towards option 2.  I just need to find out how much Melatonin is needed.

Update: On 20 mg Melatonin, the results are similar.  Very poor opener (1:51) but the NAC was a game changer (1:31).  Thym Adren didn't really move the needle much (1:33) and I may have matched it if I didn't slow down at the end.  If I had taken Endodren instead, I'm pretty sure it would have been much worse.  

It's tempting to add more NAC because I did so much better on 1 pill but remain so far below my peak.  I know what happens if I try mega doses.  I will require more Melatonin and won't get any better.

I will continue to gradually cut the Melatonin dose in hopes that 5 mg is enough to tolerate NAC at low doses.  I'll take 15 mg tonight and I should be better in the opener.  I do hope that the NAC gap will eventually diminish.

Caffeine has turned bad.  The ill-effects are not as dramatic as before the Melatonin but significant nonetheless.  Opened with an 81 then slipped to an 87 after a Red Bull.  NAC was still effective (75) but the positive effects were not as dramatic this evening.  I should be okay with an occasional Coke but it's time for Red Bull to go.

Tuesday, December 17, 2024

NAC and Detox

 I found this by accident.  I saw that I had about 30 NAC pills left in my bottle.  Just like the Liver, the plan was to take 2 or 3 per day until the bottle was empty.  I did not plan to re-order but did view it as a test for Demand #1.  I should not see a major reaction one way or the other.  A bad reaction to Liver pills is understandable but NAC should be well tolerated, right?

WRONG.  I was beyond awful last Friday morning and by the evening, I was also reacting badly to Taurine.  I never really thought to take Molybdenum for a Sulfur excess.  Even if that was the problem, it should not feel like this.  Moreover, a Sulfur excess should not develop after just a day or two.  My first thought was to increase the Melatonin.  Much to my relief, I was better after an extra 3 mg and the NAC was tolerated again.  I decided to double my dose to 10 mg that night.

The next morning, my opener was a pitiful 2:00 for a half lap.  I figured that I would need Endodren to get better but wanted to test out the NAC first.  I expected to be about the same, give or take a couple of ticks but nothing more than a marginal improvement.  Much to my surprise, I clocked a 1:45, 90 seconds faster per mile.  Enough to be considered a game changer.  In the real workout, the story was the same.  I was awful in the first half but popped a NAC at the turnaround.  The back half was still bad but much less horrible.  Unfortunately, by the evening, I was fading again and could sense that my system was demanding more Melatonin.  Again, it helped.

Next morning, the plot thickened again.  Despite the increased dose, I already needed more by the morning.

I saw no other way other than to load on Melatonin until the NAC was tolerated.  Even if the side effects were bad, it's still preferable to the inexplicable reactions.  The story was the same the next morning.  I opened with a 2:11 then fared no better on NAC.  Melatonin brought it down to a less horrible 1:48.  I took Melatonin until the side effects kicked in.  I don't even know how much I took (not recommended). But at least I knew that there was still a dose that shut off the inexplicable reactions.  

This morning was interesting as well.  Opened with a 2:05 on mega Melatonin the previous night.  Down to 1:58 on NAC.  Significant but not a game changer.  Then, surprisingly I was WORSE on Endodren.  In the evening, I was down to 1:52 then 1:41 on NAC.  In another surprise, I was just about the same on Thym Adren at 1:42.  So, I was significantly worse on adrenal stimulants while the suppressants did essentially nothing.  

This is heavy!  Still trying to process it.  It's clearly detox related as evidence by positive reactions to NAC (with sufficient Melatonin).  It's definitely better to use NAC for detox than Endodren.  The plan is to take as much Melatonin as I need to tolerate NAC but no more than necessary.  I don't know what that dose is just yet.  I will load on the NAC.  

Thursday, December 5, 2024

Training 12/5-12/15

 12/5- AM- Opened with an 85 at Montreat and improved only to 83 after taking Endodren.  Not a significant improvement.  

PM- Able to squeeze in a daylight run at Millbrook following a training class at work.  Half mile in 4:00 then drank a Red Bull and walked a lap.  Improved to 3:58 but I'd actually rate the 2nd interval as slightly worse.  I had to turn up the effort quite a bit to break 4.  

Distance-1.5

Reaction:  If current trends continue, I no longer need stimulants to ease the detox symptoms.  It's possible but unlikely that Liver is messing with my chemistry.  I'm just finishing that bottle to get rid of it.  Tomorrow, I will go back to Thym Adren.  If that's tolerated, I'll quit the Liver for a few days to rule out its impact then finish the bottle and pitch it.

12/6- Opened with a 1:42 half lap at Montreat.  Popped a Thym Adren and improved to 1:32.  I expected to tolerate it.  Did not expect a significant improvement.  I could see a massive adrenal spike this weekend.

Distance-0.5

12/7- Adrenals have spiked BIGLY.  Opened with a 3:38 lap (10:54 pace).  Popped 3 Thym Adren and did the next 2 laps in 6:35 (9:52 pace) for an overall time of 10:13.  A single pill probably won't make a significant difference.  That's good and bad.  Maybe I will finally see steady improvement going forward.

PM- Taurine helped and caffeine didn't hurt.  Down to 83 for a half lap then 81 after a Red Bull.  I'm still planning to cut the caffeine.  I could be hurting badly by tomorrow evening.

Distance-1.5

12/8- Dipped under 90 on a half lap without pills.  Real workout went about as expected.  2 miles on Lakeshore in 19:16 (9:38 pace).  Very even splits.  This is sub-60 pace for 10K but I don't think I could have held it much longer.  I decided to taper off caffeine.  Next week could be rough.

Distance-2.5

12/9- Repeated the 2 mile distance at Lakeshore this time in the evening.  Improved to 18:32 (9:16 pace) with splits of 9;08-9:24.  Struggled a bit on the back half but the 9:24 is still faster than yesterday.  This was just about what I expected and hoped for.  A solid MINUS 22 versus yesterday but that's not a night and day difference.  Maybe extra Thym Adren or Taurine could have made a difference but I will take it.  Plan to stick with 3 Thym Adren.

Distance-2.0

12/10- Step backwards.  Hoped to make 3 miles but settled for 1 in 10:27.  Last week, I suspected that the Liver pills made the adrenal spike worse.  Looks like I was correct.  I will finish the bottle and not re-order.  Zinc may help with that.

Distance-1.0

12/11- Finished the bottle of Liver pills and chucked it.  It's confirmed to be the culprit.  It's a bit unnerving to have this reaction but it's probably not inexplicable.  It likely increased adrenal activity, which is not what I need at this point.  Moreover, I took 3 pills for several days to finish the bottle.  If I had taken just 1 occasionally?  Probably okay. 

 Opened with a 1:57 half lap (11:42 pace) and improved to 1:49 (10:54 pace) after 2 Thym Adren.  It helped but not nearly enough to get back to form.  I'll be okay once the Liver clears.  That's it for today.

Distance-0.5

12/12- Repeated the morning sprints.  Improved to a 1:38 (9:48 pace) on the opener and a 1:31 (9:06 pace) on the closer.  Still not even close to respectable and that's a larger gap than I would like to see but I'll take it.  I'll try to run in the evening.

PM- 1.5 miles on Lakeshore in 16 flat (10:40 pace).  About what I expected.  The Liver pills didn't mess me up overnight and the recovery won't be overnight either.  I am getting rid of the NAC now but I don't think that's an issue.

Distance-2.0

12/13- Quit after just a half mile in a time over 6 minutes.  The culprit is NAC.   The Melatonin was SUPPOSED TO STOP THIS SORT OF THING FROM HAPPENING!  A problem with Liver pills is understandable but I don't see why I would reject NAC.  This might be an inexplicable reaction.  If so, I have no words 

PM- Confirmed that the inexplicable reactions are back.  Fortunately, the Melatonin remains effective.  I just have to increase the dose.  Did a few strides and felt MUCH BETTER after increased Melatonin.

Distance-1.0

12/14- #1.  Intervals.  Opened with a pitiful 2:00 half lap.  Popped a NAC expecting it to do nothing, marginally faster at best.  Improved to 1:45, which is significant.  Endodren (not Thym Adren) brought me down to 1:24.  As it looks now, if I need Thym Adren, I'm not detoxing like I should be.

#2- 1.5 miles on Lakeshore in 15:24 (10:16 pace).  First half was 8:04 then popped a NAC and improved significantly again.  The back half was  decidedly LESS HORRIBLE at 7:20, faster by nearly 1 minute per mile.  The very same pill that I couldn't tolerate yesterday?  I needed it today.  What a life!

Distance-2.0

12/15- Junk intervals was all that I could do.  It is clear that more Melatonin is needed.

Distance-0.5

-Totaled 15 miles

Wednesday, December 4, 2024

Verdict on Melatonin

 HOPEFULLY MY LAST POST ON THIS;

5 mg is the sweet spot though a dose between 4-6 would probably work as well.  On 5 mg, I get no immediate negative reaction to Melatonin.  In fact, I am usually marginally faster after taking it.  The inexplicable reactions to other pills STOP COMPLETELY!  YUGE!  

Bump it up to 8 mg and I will feel stiff and lethargic after taking it in the evening.  I will struggle the next morning but get better in the afternoon.  Drop it down to 3 mg?  I'll be okay for the first couple of days.  In fact, I can get away with at least one skipped dose.  However, by the end of the week, even on 3 mg, the inexplicable reactions will suddenly return.  It affects the adrenal balance as well.  More on that later.  As long as I stick with 5 mg almost every day, I should be relatively free of complications.  

If I take Methyl Folate almost every day like I am supposed to do, I cannot tolerate the Thym Adren (adrenal suppressant).  I am 99 percent sure that it's a detox reaction.  I must take BOTH the 5 mg Melatonin AND the MF to trigger the detox.  If I skip the MF OR take the reduced 3 mg Melatonin for more than a couple of days, BAM!  Once again, I need the Thym Adren and at mega doses.  I don't think Glycine is a factor after all.  I still need it but it's not a critical pill.  I won't notice until I go 5 days without it.  

Again, there are no immediate ill-effects from the Melatonin but the the story with Methyl Folate is a little different.  I do feel a bit of a let down after taking it but the ill-effects are not severe.  On a test interval, I am usually 30-45 seconds slower per mile after taking MF.  I usually have to pee shortly thereafter and feel a bit better after doing so.  

With Endodren (adrenal stimulant), I am usually 45-60 seconds faster.  Same with Red Bull.  Helpful but not a game changer.  I've read that caffeine can aid in detox.  Speeding up the oxidation rate will get the toxins out faster. 

  I fully expect that this is only a temporary reaction and I won't have a permanent need for Endodren.  I may be left with BADLY UNBALANCED adrenals when this is over but maybe not.  I've read that toxic metals can trigger fast oxidation.  Perhaps that was the source all along.  Therefore, there is a chance that I won't be as dependent on the Thym Adren when it's over.  

I have no choice but to roll with the detox process and hope for gradual but steady improvement.  How long will it last?  Likely, at least a couple of months.  Maybe a year.  Endodren will speed up the process but I prefer not to rely on caffeine even if it improves my symptoms.  

Why might this be different than previous false hopes?  I've never reacted like this before.  It usually starts with an insatiable need for the pill.  The need gradually diminishes until it becomes ineffective and leaves me back where I started.  There is no insatiable need for Melatonin.  I don't think I get much gain from mega Endodren either.  For the last time, I don't need to be a competitive runner to be happy.  I only want enough energy to be productive and enjoy life.  That can only happen if I have no extreme reactions or extreme need for pills 

Sunday, December 1, 2024

2024 Travel Stats

 Still a month left in the year but it seems unlikely that I will visit any new states in December.  Given the current cold snap, the Gulf Coast will probably be too cold for another swim until the end of March.  

22 points on the year, which is well short of last year's total of 31 but I got in more quality this year.  18 US states, 2 Canadian provinces and 2 other countries. I also completed a bucket list item by visiting my 10th and final Canadian province.

Last year, I had at least 3 states in which I didn't even drive through.  I simply walked across the border.  None of those in 2024 but I did have 3 drive through only states.  I also had an airport layover in Dallas, Texas but that doesn't count on any level.

Virginia 

West Virginia  

Kentucky 

I did stop for gas and/or a meal in all of these states.  In Virginia, I took a scenic detour but did not stop at the nearby state park.  If I had gone on a short hike (even 5 minutes), it counts for the next tier.  An overnight stay in West Virginia also only counts for the lenient standard.

Single day visit:

Mississippi- Day trip to Hattiesburg 

Tennessee- Day trip to Chattanooga

Georgia- Stop at Monticello to see My Cousin Vinny courthouse.  Walking tour of town.

New Jersey- Liberty Park in Jersey City.

Maryland- Deep Creek State Park 

Ohio- Cut a tire on the road north of Cincinnati.  Had to call the tow truck.  No tourism but I say this counts for the strict standard.

Multiple day visit-

Florida- Gulf and Atlantic coast 

South Carolina- 2 dips at Myrtle Beach.  A little weak but it counts because they were on different days.

North Carolina- Surf City, Carolina Beach, Ocean Isle.

Colorado- Denver, Breckenridge, Colorado Springs 

Nevada- Reno and Lake Tahoe 

California- Tahoe, San Francisco and Yosemite

New York- NYC.  Manhattan, Bronx, Queens and Brooklyn.

Pennsylvania- visit family.  Steelers museum in Pittsburgh.  

Ontario- Toronto 

Newfoundland- St. John's 

Dominican Republic- Punta Cana and Saona Island.

Turks and Caicos- Beaches Resort

Lived-

Birmingham, Alabama 

Edit:

Saw 4 new baseball parks, which brings that total to 18.  

New York Yankees 

New York Mets

Toronto Blue Jays

San Francisco Giants 

Tuesday, November 26, 2024

Florida Atlantic Trip

 I did travel for Veterans Day.  Not an all time great trip but still worth a share.  I considered the Louisiana coast, the Arkansas and Oklahoma mountains and Florida Atlantic.  I went with option 3.  Not a bad call but perhaps the weather would have been better in Arkansas.  Louisiana was out because of a tropical storm in the Gulf and I wasn't sure where it would turn.  Mountains would have been nice at peak foliage but I didn't think we were quite there yet.  What sealed it was a smokin' deal on a beachfront motel in Flagler Beach for just $70 per night.  That would be my home base for 2 nights.  

11/8- Left work early and drove just beyond Tallahassee.  It still makes me smile to cross into Florida.  




11/9- First stop was Jacksonville.  I elected to take a dip there in the morning then head down to Flagler for an afternoon session.  I found a radio station that was playing all Christmas music.  So, here I was listening to songs about snow while on my way to shred some waves in 80 degree weather.  Water temperature was around 75.  I love FLA.  






11/10- Mostly overcast today with a little rain.  A bit of a downer but it didn't wreck the trip.  Most of the rain came at lunchtime and I still salvaged a decent surf session.  The weather may have been a little better 30 minutes south in Daytona but I elected to stay at the home base.  Flagler has a chill vibe and is less touristy than nearby Daytona.




11/11- Left Flagler after sunrise and stopped in St. Augustine.  I got a free tour of the fort because it was a Federal holiday and squeezed in a dip at Vilano Beach nearby.  Conditions were nearly perfect.  I really didn't want to leave but I needed to get home at a decent hour.  Went back through Georgia via 280.  













Monday, November 25, 2024

MTHFR and Detox

 I experienced a flip flop flip with regards to the adrenal balance last week.  I went from an adrenal spike to need for stimulants to back to an adrenal spike.  Now, I am back on the stimulants.  What a life!  Good news is that I think I know why the flip flop flip happened.  I need a consistent supply of Methyl Folate for the detox to proceed.  The toxins are not being released in batches as I had originally feared 

Yes I do have the dreaded homozygous genetic mutation for MTHFR 677.  I believe that I am hetero on 1298 but I'm not sure.  I know I'm not homo on 1298.  It's either hetero or no mutation.  In any event, I need to take Methyl Folate in a specific form.  I take it with TMG, Intrinsic Factor and B12 but up until now, it was not a critical pill.  

By not a critical pill, I mean that I can afford to miss a dose every so often.  I won't start to feel off until I go 4 or 5 days without it.  That's what SHOULD happen with every pill.  Because of that, I am not as disciplined about taking it as I am with the Thym Adren.  Since, it is heavily involved with detox especially Mercury, it has become a critical pill.  

On the days that I do take the MF, I am sluggish and stiff.  I feel BETTER on Red Bull and Endodren (adrenal stimulant).  If I go 2-3 days without it, I experience a reversal.  I am overstimulated and require mega Thym Adren.

This is almost certainly a detox reaction.  I am 99 percent sure.  MF must be taken every day, preferably at night.  Otherwise, the detox cannot proceed.  As for the Melatonin, I had no immediate reaction.  In fact, I was marginally faster after taking it.  However, I will try to reduce that dose in hopes that the detox will be more manageable.  I have no choice other than to take Endodren temporarily but I will try to limit the caffeine.  Fast oxidation helps speed up the detox process.  

Eventually, the toxins will clear and I will be left with badly unbalanced adrenals.  At least I should not flip flop if I am consistent with the MF.  How long will I have to stay on Endodren?  Who knows?  I predict that the reversal will come suddenly.  I can deal with that as long as I don't keep flipping back and forth.  

I've read that 91 percent of people with Autism have the MTHFR homo mutation.  8.5 percent have the homo mutation.  It's very possible that none of this would have happened if I had better genes.  That makes me VERY ANGRY!

Monday, November 18, 2024

Training 11/18-24

 11/18- Felt better when I woke up today and opened with an 81.  Marginally slower after drinking a Red Bull (83) then MUCH WORSE after Endodren (1:44).  Actually, I interpret this as GOOD NEWS.  I no longer need stimulants to cope with the detox.  It remains to be seen if I will be better or worse tomorrow back on Thym Adren, which is what is suitable for my chemistry.  Eventually, I will need it again.  

PM- Half mile in the dark at Montreat in 5:49 (11:38 pace).  That's okay.  Consider this the starting point.  I should be a little better almost every day going forward.  Tomorrow will probably be rained out but I hope the effect of the Thym Adren will be clear one way or the other without a test.

Distance-1.0

11/19- AM-Forced myself to go in the rain.  Opened with a 1:51 then improved to 1:46 on Thym Adren.  Helpful but not a game changer.  At least it didn't hurt me.  I am slow because of detox not unbalanced chemistry.  I went back up to 5 mg Melatonin but I don't think that was a factor.  Even if it was, if I can function, I want to get the toxins out as quickly as possible.

PM- Repeated the half mile on the same route.  Improved to 5:14 (10:28 pace).  Nice improvement.  Keep it up.

Distance-1.0

11/20- Better than expected.  Full Mile at Montreat in 9:17.  Even pace without much of a push at the end.  Took all the pills before the run but I don't think I would have been much worse without them.  Demands #1 and 2 are met at least for now.  I've got a ways to go on #3.  Figure I am about a quarter of the way to a sub-60 10K

Distance-1.0

11/21- Adrenal spike hit yesterday afternoon.  Not unexpected.  How long will it last?  In the past 2 weeks, I experienced a spike, stabilization, need for stimulants and now another spike.  What a life!

Opened with a 1:54 then improved to 1:43 on 2 Thym Adren.

Distance-0.5

11/22- Better.  Full mile in 9:24 after a 1:38 start on no pills.  Comparable to 2 days ago but still feel overstimulated.  Good news:  Another former problem pill called Quercetin is now tolerated thanks to the Melatonin.  Unfortunately, I am afraid that there will be multiple rounds of detox.

Distance-1.0

Weekend- BAD! May have discovered something however.

Distance-1.5

Sunday, November 17, 2024

Melatonin Detox Reaction

 Nothing should surprise me anymore but this latest false hope REALLY HURTS!  I've run little to nothing in the past 10 days and missed out on another local 5K.  It's looking like once again, I will not be racing at all this calendar year.  

At first, it appeared that adding back the Glycine would stop the adrenal spike and reduce my dependence on both the Thym Adren and the Melatonin.  It did that.  Only problem is that now, I can't tolerate the Thym Adren.  I need adrenal stimulants just to function.  

Has my metabolism flipped?  Highly unlikely.  I am over 90 percent sure that it is a detox reaction.  How long will it last?  Who knows?  I do except that it will flip back suddenly.  One day, I will need stimulants.  The next day, I will be back to the suppressants with a worsened adrenal imbalance.  What a life!  Indeed, Melatonin is involved with detox of heavy metals such as Lead and Mercury.  What angers me about this is that I already went through Hell with the TRS spray.  I thought I had already gotten most of those toxins out.  Apparently not.  I just can't plug all the leaks.  I cannot solve one problem without creating another.

Any good news?  Yes.  It appears that I am less dependent on the Melatonin.  Recently, I reduced the dose from 5 mg to 3 mg and the inexplicable reactions to Colostrum and Taurine returned.  2 nights ago, I didn't take ANY pills.  What were the results?

Opened with a 94.7 then actually improved to a 90.5 on the formerly problematic pills.  On Endodren (adrenal stimulants), I improved significantly to a 78.0.  Last night, I was back to the usual 5 mg and the result was worse.  I opened with a 1:45 then dropped to 1:30 on Endodren.  I tried again after a forbidden energy drink.  Again, I improved significantly to a 1:24.  

What now?  

I don't think I have any other choice but to let the detox run its course.  I am betting that it was not a Melatonin deficiency that triggered the reactions but toxic metals.  Melatonin will get them out.  I will reduce the dosage to make it manageable.  If I stop completely, I can probably get away with it for a few days but the inexplicable reactions will eventually return.  

Wednesday, November 13, 2024

Glycine Stops Adrenal Spikes

 I've hit a couple of bumps in the road over the past week or so.  Fortunately, the Melatonin remains effective and well tolerated at 5 mg.  By that I mean that the inexplicable reactions stop and I am not so stiff and lethargic after taking it.  If that continues, Demand #1 has been met.  That's the one that is most important to me.

Demand #2 looked to be a NO just a few days ago.  I need 5 mg of Melatonin every day.  If I drop it down to 3 mg for just 2 days, the bad reactions to pills come back with a vengeance.  I haven't even tried to see what happens if I don't take it.  Some night, I will forget to take it and I expect to be rudely reminded the next day.  

Still, as long as the Melatonin dose remains constant at 5 mg, I can live with that.  Please, no moving targets!  My need for Thym Adren shot up last week.  I thought it was an adrenal spike, which is common after solving a major problem.  Nope.  It was because I stopped taking Glycine.  I thought I no longer needed it but I was wrong.

6 pills was probably the best dose.  If I cut it down to 3, I was okay on the first day, a little off on the second day and downright awful on the third day.  No, I could not get away with even one day off the Thym Adren.  Not acceptable.  

Things changed when I went back to the Glycine.  The need for Thym Adren diminished.  3 pills will be effective but 6 will be too much and I'll feel the ill-effects of overshooting for a couple days.  If I get in an equilibrium on 3, what happens?  I probably won't notice if I accidentally take extra for just 1 day.  Also, I won't start to feel a little off unless I go maybe 3 days without it.  That's acceptable.  Will the Glycine reduce my dependence on Melatonin?  That remains to be seen.  Also, it's possible that cleaning up my diet will affect the balance point.  There is no extreme dependence on Glycine.  I won't notice until I go about 5 days without that stuff.  

Demand #3 is enough energy to be productive and enjoy life.  I did enjoy my trip to Florida last weekend but if the surf had been much rougher, I may not have had the strength to be out there on consecutive days.  Not acceptable.  I only did a couple of junk runs and still can't race.  I was hoping to jump into a local 5K this coming weekend but that looks unlikely.  I believe that if I meet demands 1 and 2, #3 will naturally follow suit