Weather is going to be cold, and/or rainy and windy all week so I anticipate being indoors most of the time.
I've decided to skip the Mercedes 5K because I don't think I'll be competitive.
2/16- AM. VERY POOR. 3 miles in 25:49 (8:36 pace). Perhaps the SAM-e has not cleared. I may be overly sensitive to the methyl donors, which accomplishes nothing. Just trading one sensitivity for another.
PM- WORSE than this morning. Hell, I ran better when I had the flu last week. It is becoming increasingly clear that I have indeed TRADED ONE SENSITIVITY FOR ANOTHER! Tomorrow morning will confirm it. Covered only 1 mile and my time was over 9.
Update: I have ordered the 23 and Me genetic test. I may not get the results for another 2 months so that changes the plans to shut down the blog. The training updates will stop after 3/21 however. It's just been too depressing lately. It's almost a certainty that something abnormal will show up and highly unlikely that it will be a quick fix.
2/17-AM. 2 miles in 15:28 (7:44 pace). Big improvement over yesterday afternoon. Took just a trace of DMG afterwards and I was MUCH worse. The methyl donors are OUT. How much do you want to bet that the zinc/copper sensitivity will kick in with a vengeance next week? I am off caffeine again but that hasn't helped me in the recent past.
PM- Took the afternoon off as planned. Picked up a B-complex at the health store with methylated Folate and methylated B-12. I'll wait a couple days before trying it. The genetic test should arrive by the end of the week. It's a painless saliva test.
2/18- Felt pretty rotten when I woke up and figured that I would have struggled for a sub-8 pace. Took the Raw Vitamin Code B complex and began feeling better shortly thereafter. BINGO!
3 miles in 21:23 then popped some B-12 alone and did the same distance in 21:37. That's not a significant change in pace so figure that the extra B-12 had no real impact one way or another Good news I suppose. Took another B-complex and ran another mile at the same effort in 7:09. Total distance was 7 miles in 50:09 (7:10 pace). I may salvage a respectable showing in Arizona. Don't write me off just yet.
This is NO cause for celebration! I'm not on solid ground with the zinc/copper and I took 3 B-complex today. How much will I need/tolerate tomorrow? Your guess is as good as mine. As for the Bs, I need a specific form the the vitamins. If I took the synthetic form of folic acid rather than methyl folate, I'd do more harm than good if I am positive on the MTHFR mutation. Same with B-12, it's got to be the methyl form or I could have a slight build up of cyanide. I'm going with the Raw B complex. It's RAW man!
2/19- Felt pretty rotten when I woke up but got better after taking the 1st dose of the B-complex. Got worse after the 2nd dose. Attempted a tempo and I knew before the end of the 1st lap that I didn't have it. Quit after 1 Mile in 7:30. Took a zinc pill and ran the same distance in 7:24. Took a liver pill and ran it again in 7:28. That's not a significant change in pace so the zinc/copper sensitivity is still manageable.
It is clear that something in the B-complex is helpful and something else is harmful. I did some experiments and determined that it is B-6 that is the problem. I can take only limited doses of it (no more than 10 mg). It's becoming increasingly clear that I am an OVER METHYLATOR, not an under methylator. If that's the case, niacin (B-3) could be helpful.
2/20- The excess B-6 may not have fully cleared but I still managed a decent workout today. Ran the opening Mile in 7:24 then gave Niacin a shot. Tacked on 4 more in 29:09 (7:17 pace) for an overall time of 36:33 for 5 miles at moderate effort. Overall impression of the Niacin is that although it was not a miracle cure, it was a net positive impact. Without it, I probably would have slowed to the 7:30s so that is a significant difference. I did get a pretty hot flush so I will cut the dose in half tomorrow. Since the B-6 must be restricted, I must take other B-vitamins separately. After tomorrow's long run, I will see how I react to extra Folate and/or B-2 (Riboflavin)
Rant: My last MD flat out refused to believe that I could not tolerate B-6. Okay, so WHY DID I FEEL AWFUL WITHIN MINUTES OF TAKING IT? Then, why did I feel better after it cleared? I know now that this intolerance is likely due to a genetic defect.
2/21- Good call on skipping the 5K because I was AWFUL this morning. I cannot take the methylated forms of folate and B12. Why did I have 1 good day on the B-complex? I don't know but I may be so deficient that even the wrong form helped for a while. I may still need Folic Acid and/or B-12 but it's got to be the un-methylated form, which means that even Jigsaw Mag may have to be restricted. I've wasted over $100 this week alone on supplements that won't work.
The workout: Plan was a long run on Lakeshore and I turned around after a half mile in 4:07 then proceeded to run the back half in 4:19 for an 8:26 finish. Took some extra methyl B-12 after I got home and got even worse, which confirms my theory.
PM- Another better with or without test. Did 1 Mile in a blazing 9:16 then popped an un-methylated B-12 and improved to 7:48 with no additional effort. That's an improvement of nearly 90 seconds for 1 mile all because of 1 freaking pill! Again, there has got to be some defective enzymes involved here and it's becoming increasing clear that genetic defects are in play.
2/22- Another better with or without test this time with the folic acid. Ran the opening mile in 7:22 without it. After taking it, I started off pretty well but faded after the 1st half mile. Managed a 7:20 2nd mile but was done after that. Faded to 7:55 in Mile 3 then called it quits. Overall time was 22:37 for 3 miles (7:32 pace). Poor performance. This means that I am likely positive for the MTHFR mutation.
Only 4 weeks until my deadline and it is looking bleak. I suspect that my increased ceruloplasmin has worsened the over-methylation. If not for the Cp, my zinc/copper imbalance would be far worse however. Based on what I've seen this week, I can just about guarantee genetic defects. Is it treatable? Yes. Completely reversible? Seems unlikely.
Distance= 27.0/ GPA= 16.2/8= 2.03
YTD: 229 miles. Record: 1-5 with a 2.30 GPA