Monday, March 30, 2020

Training 3/30-4/5

3/30-AM Opened with a 71 for half lap at Montreat (7:06 pace) then actually improved marginally to a 70 AFTER 100 mg of CoQ10.  The low dose will be tolerated.  Excellent news.  Probiotics and CBS/NOS brought me down to a 67 (6:42 pace).  Enough to be considered significant but I didn't feel much different.  Extra NADH was confirmed to be the culprit.  Slipped to an 81 (8:06 pace) after 10 mg.  I can probably tolerate 10 on a daily basis (5 for sure) but not after consecutive days of 25.  Added a full lap in 2:46 (8:18 pace) before my so-called work day began.

PM- Had to get out for sanity purposes.  Ended up going to Veteran's Park for 2 miles.  Wasn't expecting much and got about what I expected.  Finished in 18:18 (9:09 pace) but held the pace steady and did have a slight little kick left at the end.
Distance=3.0

3/31- Got as low as 55.5 (5:33 pace) with the stacked deck that included CoQ10.  I've done 51.9 before do that's significantly slower.  I need to be no slower than 53.  In the evening, I went to Lakeshore and my workout was interrupted by GI issues.  I was doing about 8:20 pace.  Extra CoQ10 hurt and probiotics helped but did NOT bring me all the way back.
Distance=2.0

4/1- Today, I was down to 52.9 after a 66 second opener this time with no CoQ10.  I'm going without it for the time being.  Tried it again and got MUCH worse.  Molybdenum did NOT increase the tolerance.  I don't understand why it was necessary such a short time ago and no cannot be tolerated.  FWIW, the same thing happened with Lithium last Fall.  To this day, I still can't tolerate that stuff and it was confirmed today.  Good day to experiment.  I think I've got all the questions answered (for now, that is).
Distance=1.0

No updates until further notice.  I am a MESS with the lockdown and the pills.

Monday, March 23, 2020

Training 3/23-3/29

3/23- Interesting.  Sneaked in a 2 miler at lunch in between rain showers.  Finished in 16:10 (8;05 pace).  Splits were 8:08-8:02.  Once again, very little benefit from extra CoQ10 and NADH.  I do know that 10 mg was tolerated today.  It was not tolerated before so that is good news.  Still, I was too sluggish out there today.  Extra MF + TMG made things decidedly WORSE.  BHMT is related to MF metabolism and I just got too much support in that area.  I should be back to the new normal after I am off it for a couple days.  Then, I will go back to the normal dose.
Distance=2.0

3/24- Another day classified as interesting.  MUCH WORSE after taking Taurine.  That means this is sulfur related.  3x1 lap at Montreat.
2:45 (8:15 pace)
2:25 (7:15 pace) MINUS 60 with extra probiotics
2:09 (6:27 pace) MINUS 48 with extra CBS/NOS
That's it for today.  Threat of storms in the evening with no Gold's Gym option.
Distance=1.0

3/25- 3rd straight interesting day.
AM- Opened with a promising 2:16 (6:48 pace) then took 500 mg CoQ10 and felt SLIGHTLY WORSE.  The watch showed it as I slipped to a 2:23 (7:09 pace).  PLUS 21.  Enough to be significant but not a night and day difference.  This answers all the questions.  The CoQ10 apparently affects sulfur.  That's why the BHMT and Taurine were tolerated before but not now.  I'm simply over the threshold that produces symptoms.  No doubt that extra probiotics and CBS/NOS would have helped but I chose to treat lap 3 as a cool down.

PM- Sneaked out for 2 miles on Lakeshore at lunch.  Finished in 14:54 (7:27 pace) with anti-sulfur treatments.  Felt free and easy with a first half mile around 3:30 but faded a bit after that.  I will try to get by with lower Co-Q10 doses going forward.
Distance=3.0
A very important point to consider:
Prior to the TRS, I would NOT have tolerated the CBS/NOS.  Thus, the treatment known to improve my symptoms was not tolerated.  That's the ultimate in cruelty.

Remainder of the week:
Became intolerant to CoQ10.  What the _____!  A flip flop flip from intolerance to absolutely necessary then right back to intolerance. 

I do know that CoQ10 does not contain sulfur but does activate enzymes that control its regulation so it's an indirect effect.  Probiotics help the most but I must be careful about taking too much together with TRS.  Extra NADH may be a substitute but my tolerance is limited.  CoQ10 must be reduced if not eliminated.  I can go up to 10 mg NADH.

Monday, March 16, 2020

Training 3/16-3/22

3/16- Hard to remain motivated when races are canceled and everything is in limbo.  Opened with a half lap at Montreat in 67.5 (6:45 pace) then after 400 mg of CoQ10, I improved to 51.9 seconds (5:11 pace).  Unfortunately, a 2nd 400 mg pill proved to be too much and I was worthless in the evening.  Tacked on some junk anyway.
Distance=1.0
Update:
Work has been closed due to the coronavirus.  I was a nay-sayer for quite a while and hope that I was right but whenever I am wrong, I am willing to admit it.  No official word on the Minnesota race scheduled for late April but I assume it will be either canceled or postponed.  Time will tell how severe this turns out to be.

3/17- Extremely boring day at work from home.  I dropped my CoQ10 dosage from 1200 to 800.  It was still too much.  I'm going back down to 400 and hope that it stabilizes there.  Workout was 2 miles at Montreat after "work"  and finished in 17:28 (8:44 pace) with splits of 8:30-8:58.
Distance=2.0

3/18- Dropped to 400 and it was still too much.  Just junk was all that I could do..
Distance=2.0

3/19- Very interesting.  I was awful when I woke up but got better as the day progressed.  2 miles on Lakeshore in 15:28 (7:44 pace) with pretty even splits (7:40-7:48)
Distance=3.0

3/20- With rain in the forecast, an AM run was all that I could do.  Veteran's Park was the locale.  1 lap naked in 5:45 (8:37 pace) but improved to 4:50 on the 2nd lap with CoQ10 (7:15 pace).  I believe the gap will diminish soon.    CoQ10 is still needed.    I don't believe that I will benefit much beyond 400 mg.
Distance=2.0

3/21- Collapse.  It was not the CoQ10.  BHMT was the culprit, which I previously thought to be a non-factor.  As is often the case with failed long runs, the first mile was in the low 9s but I was fading fast and had to walk some at the end.
Distance=2.0

3/22- Good news with the intervals.  Still hurting as a result of extra BHMT yesterday.  Opened with a 3:13 at Montreat (9:39 pace).  500 mg of CoQ10- Improved to 2:49.8 (8:29 pace).  MINUS 70.  That's still a significant gap and it's got to close soon.  The good news came at 1000 mg.  On the double dose, I actually improved fractionally to 2:49.2 (8:27 pace).  I need the CoQ10 but there is NO benefit beyond 500 mg.  I'll take the smallest effective dose.  Probably, 400 will do.
Distance=1.0

-13 miles on the week.

Friday, March 13, 2020

Rant: Corona Virus and Response


I am NOT very concerned about the Coronavirus.  While they say, it is better to be safe than sorry, IMHO the current panic is over the top.  Sure, reasonable restrictions can and should be undertaken.  I would temporarily close the border or at the very least ban travel to and from countries hard hit by the virus such as China, Italy, Iran and South Korea.  Those seeking re-entry to the USA should be carefully screened and infected people must be quarantined until they recover.  Refusing a handshake from a stranger should not be taken as offensive.  Wash hands more frequently and try to avoid touching your face, especially areas around your mouth, nose or eyes.  Take Vitamins, especially C, and minerals to boost your immune system.  I would not go on a cruise or travel to areas hard hit by the virus such as Seattle, New York and California. 

Out of the 350 million people in the United States, there have been (as of 3/13/20) roughly 1,000 confirmed cases and 39 deaths.  26 of those deaths were in a Seattle nursing home so that leaves just 13 others.  True, even 1 is tragic but least up to this point, it pales in comparison to the common flu and is far LESS deadly than SARS and other pandemics.  I feel that the WHO’s quoted mortality rate of 3% is an over-estimate.  I believe many people brushed off what they thought was a common flu but was in fact, the coronavirus.  I’ve heard horrific predictions that 60-70% of the globe will be infected before it’s over.  Highly doubtful.  I believe it will peak by the end of the month then begin to decline as the warm weather sets in.    If you are under 60 years of age and do not have a compromised immune system or pre-existing lung disease, your risk is practically nil.  It may take time for lung function to fully recover, as with pneumonia and bronchitis, but I doubt that many cases result in permanent damage.  On the flip side however, an otherwise healthy person could be a carrier and pass on the disease to somebody in a higher risk group.  My parents are both in their 70s and I could never forgive myself if I carelessly infected one of them and it turned deadly.  The elderly and other high-risk cases should be strongly encouraged, but not required to stay at home as much as possible and to avoid large gatherings of people.

While my energy and vitality has diminished in recent years, my immune system has actually become MORE resilient.  I do get the occasional common cold just like everyone else but in the last 4 years, I have never missed work due to illness.  I never take the flu shot but have only had the flu once in the last 15 years and it really was NOT that bad.  I was out of commission for 2-3 days and had some residual crud in my system for 2-3 weeks but after that, I was as good as new.  Bronchitis can be a little rougher with the cough and congestion and I did have walking pneumonia in middle school.  The latter took several months before I was fully recovered but eventually, I did.  I figure that if I did catch the coronavirus, the worst would be over within 5-7 days and I’d have to lay low for another week as a precaution.  I’ve been through worse.  Again, the real risk is to others in higher risk groups, but those risks can be mitigated by taking normal precautions. 

Over the past several days, we have seen schools closed and all sporting events cancelled or postponed, including my planned half marathon in Salisbury, Maryland.  The stock market is tanking, and we could see small businesses and people’s livelihoods destroyed not because of the virus but because of the panic associated with it.  One e-mail described the current panic as trying to kill a fly with a shotgun or burning down a house because it is infested with a few roaches or mice.  That’s not far off.  As for my race, the RD had no choice.  The governor decreed that all public gatherings with 250 or more attendees MUST be canceled until further notice.  I assume that must also include large church services.  Again, IMO, this is over the top but there is nothing that I can do about it.  I’ve heard some SICK (in the head) people who are actually rooting for a pandemic because it would hurt Trump’s re-election chances. 

Now, this changes the plan to finish the 50-state challenge in 2020.  My race will NOT offer any refunds but will give deferred entries for 2021.  That’s probably what I’ll do.  It’s possible that I could find another Maryland race in the Fall that would only require a flight to Baltimore with no rental car or even a 10.5 hour drive to the western part of the state but my heart was set on either Salisbury or Ocean City because I spent a summer in that area and went on family vacations as a child to Virginia Beach.  There is a chance that an early May race in Ocean City will go off as planned so that could be an option.  Odds are, I’ll just take the deferral and finish next year.

I still want to do something BIG for the year that I turn 40.  I could still go to Hawaii in November as planned but it would be state #48 or #49 then I finish up in either Maryland or Minnesota next year.  That will not feel nearly as special as #50 in Hawaii.  Option B is to book a trip with Marathon Tours and Travel to Cape Town, South Africa in October.  There, the race would be a 10K because there is no half marathon and I am not in shape for a full.  Cape Town has long been on my bucket list and I’d like to do it sooner rather than later.  South Africa has begun instituting policies that were disastrous in Zimbabwe, so I don’t have a good feeling about that nation’s future.  As stated in a previous post, things can turn around to make countries more appealing for tourists, but it can also get worse.  I’m leaning towards Option B.  South Africa in 2020 and Hawaii in 2021.  Hopefully, I can still hit Maine, South Dakota and possibly Minnesota after the coronavirus is contained.  Either way, I will make no definitive plans until that happens. 

Monday, March 9, 2020

Training 3/9-3/15

3/9- Easy 3 on the Vulcan trail.  New route.  Finished in 24:48 (8:16 pace).  I am not collapsing but this was NOT pretty at all.  I'm getting concerned that my daily workouts have not been improving.  Nice views of downtown Birmingham but the slope of the route was deceptive.  I didn't notice the downhill on the first half but I sure felt the uphill on the back half.  Still, I held the pace pretty well.  1st half was 8:09 pace and held on for an 8:23 going uphill.  I've ordered Stress Pak and BHMT.  The latter is more likely to trigger a reaction.
Distance=3.0

3/10- Disappointment.  Planned on 3.5 at the Trak Shak plus a cool.  Came through Mile 1 in 8:20 (largely uphill).  Figure I was headed for roughly the same pace as yesterday give or take a couple seconds.  I had to quit due to GI issues and no portajohn nearby.  I panicked thinking that there had to be a missing piece.  That may be true but it didn't work as I expected.  L-Dopa seemed to be HELPFUL.  I feared a possible negative reaction to that stuff.  The response to Co-Q 10 however was DECIDEDLY NEGATIVE! I expected that to be a non-factor and I'm not sure what to make of that.  Too much NDUF support with NADH?  One or the other?  OR  The Co-Q 10 will become necessary and I will go through the usual adjustment period.  Added a junk mile later but it was ugly.  I'll find out tomorrow but in retrospect, a low dopamine level is not a surprise.  I'll try serotonin support.  I have ruled out low adrenaline.  Will this ever end?
Distance=2.0

3/11- Encouraging.  6x1/2 laps at Montreat.
Opener- 94 (9:24 pace)
TRS- 92 (9:12 pace).
I thought the TRS was causing a detox reaction.  Not so.  I was marginally better.
L-Dopa- 83- (8:18 pace)
Significant Gain
Co-Q10- 73- (7:18 pace)
Significant Gain.  CoQ-10 is tolerated on its own
NADH- 64- (6:24 pace).
CoQ-10 is tolerated with NADH.  Significant gain.
2nd Co-Q10- 71- (7:06 pace)
Significant LOSS.  Noticeably weaker but it was not a killer.
Being unable to sustain a 7:00 pace for less than 1 track lap does not bode well for a real workout so that's it for today.  I'll start fresh tomorrow.
Distance=1.0

3/12- Not good.  1 Mile in 9:32.  I wasn't expected a good run or even a sub-Mendoza line effort but wasn't expecting this either.  Came through 1/2 mile in 4:45, popped a Vitamin C and fared no better.  In fact, I was marginally worse with a 4:47 on the back half.  I figured that I needed more CoQ10 and I was correct.  2 of those pills were too much yesterday but today, it WAS NOT ENOUGH!!  You never know what will happen in the week of an adjustment.  C is a non-factor but it could be useful for my immune system.

PM- Intervals on South Lakeshore.  Not sure of the exact distance but figure it was roughly a quarter mile, maybe a hair longer.
Opener- 2:18 (1 pill in the morning)
1 CoQ10- 2:02
2 CoQ10- 1:51
4 CoQ10- 1:38
Once again, I know the drill.  The gaps in performance will decrease and I will become much less dependent on CoQ10.  Within a week or two, I will be able to get by for a couple days without it.
As expected, Stress Pak is a non-factor.  It appears that the BHMT drops are also a non-factor.  Not a surprise.    This SHOULD be the final answer.
Distance=2.0
UPDATE- The race in Salisbury, Maryland has been canceled due to the Coronavirus.  There is no refund but they are allowing a free deferral for next year.  The 50 state quest will NOT be completed this year.  Nothing I can do about it.  The big trip in the Fall might be Cape Town, South Africa instead of Hawaii.

3/13- AM- An opener and closer at Montreat to test the BHMT plus a cool.
Opened with a stacked deck that included 3 CoQ10 pills and clocked a 2:23 (7:09 pace).  With the BHMT, I felt no different but the watch showed marginal improvement to a 2:20 (7:00 pace).  Most likely, it's a non-factor.  I'll probably finish the bottle and be done with it.  Added a lap cool

PM- Decided that's it for today.  Felt a STRONG need for more CoQ10 and it did help but would not have been enough for a quality workout.  I'll need mega doses for a few more days but the need will eventually diminish.
Distance=1.0

3/14- Split decision.  Opener in 1:55, which is a lot better than previous runs.  Closer in 84 seconds (5:36 pace).  Gap of 2:04 is significant but it is encouraging.  As the gap closes, the ceiling will still rise.  I believe I can go under 75 for the 400 and if I can do that, I figure a sub-6 Mile is attainable. 
BUT
When I tried to do a standard issue workout, I had NOTHING.  Even after a full recovery from the intervals.  Quit after a first mile in 8:51 and it would have been worse if not for a late rally.
Enjoyed a day in Selma with Matthew.
Distance=2.0

3/15- Not surprisingly, I felt awful without the CoQ10 and 400 mg wasn't enough.  After 800, I was noticeably better.  Mile in 7:33 with an even pace.  Took another 400 and improved to 7:10.  Much better than yesterday.  The need will eventually diminish and I'll stick with 800 for the time being.  I believe I can now do a decent standard issue workout.
Distance=2.0

-13 miles on the week.  Not good.



Monday, March 2, 2020

Training 3/2-3/8

3/2- NADH is starting to work.  It was intervals at Gold's on another rainy day.  Opener was a pitiful 3:43 (11:09 pace).  A shot of caffeine allowed me to improve only marginally for the 2nd straight day.  2nd interval was not much better at 3:40 (11:00 pace).  BUT I was all the way down to 2:30 (7:30 pace) after just ONE NADH pill.  I took a 2nd pill just to see what would happen.  I felt noticeably worse but not as bad as the opener.  Didn't have time for a 4th interval but did do a few strides.  I figured that I would have roughly split the difference for a pace around 9:00.  That's it for today.
Distance=1.0
Reaction:
I know the drill now.  Both the floor and ceiling will rise but the floor will rise much faster and that gap of 3:30 per mile will close quickly.  Tolerance for extra pills is already improving and that will continue.   Also, I should no longer need caffeine to perform.  That's excellent news.  A can of Rockstar every day is NOT good for my long-term health.  I am just under 5 weeks out from Maryland now.  There are 2 other pills that I'd like to try but I predict both will be non-factors.  After last week's long run, I have reason to hope.

3/3- Canterbury 3.5 miler in 31:27 (8:59 pace).  Not great but not terrible.  This is a hilly route.  I was comfortably under 9:00 pace all the way but had to slow down at the end because the trail was a bit treacherous in the dark.  Added a half mile cool.  I expect to continue to improve this week.
Distance=4.0
Felt better after taking another NADH.  I may have to go with 2 of those for the time being.  Hope it's not for long.  This stuff is expensive.

3/4- The second NADH pill was NOT such a good idea after all.  Planned on 3-4 at Gold's and had to quit after 1 in 8:45.  Started off pretty well but faded bigly after the first half mile.  Downed a can of Red Bull and again improved marginally.  2nd mile was 8:41.  Caffeine is basically a non-factor.  What slowed me down today was the 2nd NADH pill.  I'll stick to one of those and should be okay.
Distance=2.0

3/5-AM- 1 lap at Montreat in the rain with no pills.  Time improved to 2:46 (8:18 pace).  That's nearly 3 minutes per mile better than just 3 days ago.  I expect that the ceiling is better than 7:30 pace but not by nearly as much.  I doubt that I have a sub-6:00 pace in me right now and even 6:30 might be a stretch.  The gap is closing as expected.

PM- 2.5 miles at Gold's in 20:30 (8:12 pace).  Not great but I am improving.  Added a short cool.  Faded on the back half (10:07-10:23).
Distance=3.0

3/6- AM- Opener in 2:28 (7:24 pace).  My floor is higher than my ceiling earlier in the week.  Good news there.  Bad news is that my closer was a rather disappointing 2:08 (6:24 pace).  The gap has closed to 60 seconds but my ceiling ought to be closer to 5:24 instead.  1 lap cool.

PM- Naked out and back 3 miler on Jemison trail.  Once again, nothing great but not terrible either.
Distance=4.0

3/7- Skipped the Wine 10K this year in favor of a 10 mile training run.  Route was the double Trak Shak 5 and finished in 87:18 (8:44 pace). Back half was actually slightly faster this time.   9 of 10 miles were under 9 and closed with a solid 8:08.  Once again, I had plenty left in the tank and I believe I had another 5K in me at this pace.  That would be a sub-1:55.  Not significantly better than last week but that's okay.  I'm still adjusting to the NADH.  2 more treatments will be tried but I expect both will be non-factors.  Maybe next week, I'll try for 13+.
Distance=10.0

3/8- Spring Forward Day.  Did 3 miles at Veteran's Park in 24:30 (8:10 pace).  Not bad for the day after a 10 miler.  Faded a bit on the back half but it was not a collapse. 
Distance=3.0

-27 miles on the week.  A little low but I'll take it.  This was an adjustment week.  Should be back over 30 next week.